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How to raise VO2max without losing strength

What the interval and concurrent-training studies show about raising VO2max while you lift: the 4x4 trial, the meta-analyses, and where it fits your week.

To raise VO2max, train your aerobic system consistently and add hard intervals: both steady training and intervals work, and intervals work a bit better. In the best-known trial, four 4-minute efforts at 90 to 95% of max heart rate, three times a week for eight weeks, lifted VO2max 7.2% in moderately trained men.1 Lifting alongside doesn't stop that from working, and the strength cost of adding intervals is small if you keep them away from your heavy leg days.

What actually raises VO2max#

The cleanest summary is a 2015 meta-analysis of 28 controlled trials in healthy adults aged 18 to 45.2 Compared with people who didn't train, steady endurance work raised VO2max by about 4.9 ml/kg/min and high-intensity interval training by about 5.5. Head to head, intervals came out ahead by 1.2 ml/kg/min, with a confidence interval that runs from 0.3 to 2.1.

VO2max gain by training type
VO2max gain by training typeEndurancetraining vs no t…3.5–6.3 · 4.9Intervals vs notraining4.3–6.7 · 5.5Intervals vsendurance traini…0.3–2.1 · 1.202.557.5 ml/kg/minVO2max gain by training typeEndurance training vsno training3.5–6.3 · 4.9Intervals vs notraining4.3–6.7 · 5.5Intervals vsendurance training0.3–2.1 · 1.202468 ml/kg/minVO2max gain by training typeEndurance training vs notraining3.5–6.3 · 4.9Intervals vs no training4.3–6.7 · 5.5Intervals vs endurancetraining0.3–2.1 · 1.202468 ml/kg/min
VO2max gain by training type
Low (ml/kg/min)High (ml/kg/min)Mark (ml/kg/min)
Endurance training vs no training3.56.34.9
Intervals vs no training4.36.75.5
Intervals vs endurance training0.32.11.2

Mean effect and 95% confidence limits from Milanović 2015 (28 controlled trials, 723 adults, mean baseline 40.8 ml/kg/min).

Read that chart the right way round. The big win is training at all. Intervals add a bit on top. That matters if you lift, because it means the easy running you already do isn't wasted, and you don't need to turn every run into a suffer-fest to move the number.

The people in those trials were 25 on average and started at 40.8 ml/kg/min. The same analysis found bigger interval gains in people who started less fit,2 so if you've been training for years, expect less than the averages.

A second meta-analysis, focused only on intervals, pooled 37 studies of sedentary or recreationally active people under 45 and found an average gain of 0.51 litres per minute (95% CI 0.43 to 0.60).3 The subset that used longer intervals showed bigger gains, around 0.8 to 0.9 litres per minute, with a marked response in every subject. That's the closest thing to a hint that the length of the work bout matters.

Why hard intervals work#

VO2max is limited mostly by how much oxygen your heart and blood can deliver to working muscle, not by how much the muscle can extract, and when training raises VO2max it's mainly through a bigger maximal cardiac output.4 That lines up with what the 4x4 trial measured: alongside the VO2max gain, the interval groups' stroke volume went up about 10%.1

The practical upshot is that intervals train the delivery side by holding you near your ceiling for minutes at a time. Easy running does a lot of other useful things, but it doesn't spend long up there.

It also explains why you don't strictly have to run. If the limit is mostly central, any mode that uses a lot of muscle and drives your heart rate to 90 to 95% of max should train it. That's an inference from the physiology, not a head-to-head trial, so if you race on your feet, do at least some of your hard work on your feet.

Longer reps, or shorter?#

Both work. In Helgerud's trial the 15-second and 4-minute versions both beat steady running, with the 4x4 slightly ahead (7.2% against 5.5%), but the abstract doesn't report a significant difference between those two.1

The meta-analyses lean towards longer work bouts. Against steady endurance training, interval programs with longer repetitions added about 2.2 ml/kg/min more (plus or minus 2.1), and programs with more work relative to rest added about 1.6 (plus or minus 1.5).2 In the interval-only meta-analysis, the subset with longer intervals showed the biggest gains.3 None of that is precise, and the confidence limits are wide. But if you're picking one session, the 4x4 is the one with the best track record.

The 4x4, in detail#

Helgerud's 2007 trial is worth knowing properly, because a lot of "best VO2max workout" advice is a loose version of it.1

Forty moderately trained men were split into four groups and trained three times a week for eight weeks. The trick was that every group did the same total amount of work, measured as oxygen used, just at different intensities:

Group What they did
Long slow distance Continuous running at 70% of max heart rate
Lactate threshold Continuous running at 85% of max heart rate
15/15 intervals 15 s at 90 to 95% of max, 15 s at 70%, repeated
4x4 intervals 4 min at 90 to 95% of max, 3 min active rest at 70%, four times

Only the two interval groups improved VO2max significantly more than the others. The 15/15 group went from 60.5 to 64.4 ml/kg/min (5.5%), the 4x4 group from 55.5 to 60.4 (7.2%), and stroke volume, the amount of blood the heart pushes per beat, rose about 10% after interval training.

Two details people skip. These men were already fairly fit, so this isn't a beginners-only effect. And the slow and threshold groups weren't lazy: they did the same total work. The difference was intensity.

The way I explain it: the interval is the work, the jog between is the recovery, and the rest period is doing as much work as the effort itself. Cut the rest short and you're not training the same thing anymore. In the 4x4 the 3 minutes aren't standing still either. They're an easy jog at about 70% of max.

Turning it into numbers#

You need your real max heart rate for this, not 220 minus your age. The highest your watch has seen in a genuinely all-out effort is a reasonable stand-in.

Mine is 194, the highest my watch has recorded. That puts the 4x4 work bouts at about 175 to 184 bpm and the recovery jogs at about 136. The whole session, four work bouts and the recoveries between, runs about 25 to 28 minutes before your warm-up.

Getting it wrong#

There are three easy ways to get it wrong. The first is running the recoveries too hard. In the trial they were an easy jog at 70% of max, so the next work bout could actually hit 90 to 95%.1 The second is going out too fast on the first rep and fading, which turns a 4x4 into one hard rep and three survival efforts. Aim for four reps at the same pace or the same heart rate. The third is guessing your max heart rate from an age formula. In 3,320 healthy adults with a verified max test, the best age formula still had a standard error of 10.8 beats per minute,5 so a guessed max can put every target off by 10 beats or more in either direction. The highest heart rate you've seen at the end of an all-out race is usually a better number.

If four reps at that intensity is new to you, three is a reasonable way in. Add the fourth when three feels controlled.

Doing it while you lift#

Here's the part the VO2max articles skip. Does adding intervals cost you strength?

A 2018 meta-analysis looked at exactly this: high-intensity interval training added to resistance training, against resistance training alone.6 Muscle growth and upper-body strength gains were the same. Lower-body strength gains were a little smaller, an effect size of minus 0.25, which is small and only just statistically significant.

The broader concurrent-training picture agrees. A 2022 meta-analysis of 43 studies found adding aerobic work didn't compromise maximal strength (SMD minus 0.06) or muscle growth (minus 0.01), though explosive strength took a small hit, mostly when both were done in the same session.7 For trained lifters specifically, another meta-analysis found lower-body 1RM gains were blunted when endurance and strength work shared a session (minus 0.66) but barely at all when they were done in separate sessions (minus 0.10).8 The interference effect article goes through these in more depth.

Bike or run?#

This is where the evidence argues with itself. An older meta-analysis found running, not cycling, caused the strength and size losses, and that more frequent and longer endurance work cost more.9 The 2018 interval meta-analysis found a trend the other way: cycling intervals hit lower-body strength harder than running intervals, though neither subgroup reached significance.6 And the 2022 one found no difference between the two at all.7

So pick on practical grounds. If your legs handle impact badly the day after squats, a bike or rower interval is fine. If you race HYROX, you'll want most of your hard work on your feet anyway.

Where it goes in your week#

Here's a real week from my log, 14 to 20 September 2026: three runs of about 7 km on Monday, Wednesday and Friday, lifting on Tuesday, Thursday and Saturday, nothing on Sunday.

One week from Ken's log, 14 to 20 Sep 2026
One week from Ken's log, 14 to 20 Sep 2026RunLiftMon3535 minTue4040 minWed3434 minThu2424 minFri3535 minSat4343 minSun0 minOne week from Ken's log, 14 to 20 Sep 2026RunLiftMon3535 minTue4040 minWed3434 minThu2424 minFri3535 minSat4343 minSun0 minOne week from Ken's log, 14 to 20 Sep 2026RunLiftMon3535 minTue4040 minWed3434 minThu2424 minFri3535 minSat4343 minSun0 min
One week from Ken's log, 14 to 20 Sep 2026
Run (min)Lift (min)Total (min)
Mon35035
Tue04040
Wed34034
Thu02424
Fri35035
Sat04343
Sun000

Session minutes by day from Ken's hybridAF training log (runs from his watch, lifting from the watch's strength records), read 2026-10-22.

Every run over 5 km I logged from early September to mid October looks like that: 5.4 to 8.4 km, average heart rate between 145 and 166, and none of them logged as an interval session. That's a fine base. It's also exactly the shape the research says leaves a little VO2max on the table.

The fix in a week like that is a swap, not an addition. Turn one of the three runs into a 4x4. Which one depends on your legs. Put it on a day after an upper-body or light lifting day, so you start it fresh, and keep it at least a few hours from heavy squats or deadlifts, ideally on a different day. The same-session cost in Petré's data was large; the separate-session cost was close to nothing.8

Keep the other runs easy. Polarized training, mostly easy with a small dose of hard, beat other intensity mixes for VO2peak in a 2024 meta-analysis, though only modestly (SMD 0.24, 95% CI 0.01 to 0.48) and with no difference in time-trial performance.10 The 80/20 article covers that debate.

One session a week is a starting dose, not the Helgerud protocol, where the groups did their sessions three times a week. If you're also lifting three or four times a week, one hard session is a sensible place to begin. Add a second only if your lifts hold and you're recovering. The weekly split guide shows how to lay out three to six days.

What to expect#

Nobody can promise you a number. Endurance training studies often show modest changes and very limited responses in some people, which is part of why Bacon's group went looking at intervals in the first place,3 and every trial here reports a group average, not what happens to you. What the evidence does support: consistent aerobic training plus a weekly dose of hard intervals should move VO2max over a couple of months, more if you're starting low, less if you've trained for years.

Measure it the same way before and after: the same 5K course, similar weather, or the same watch on the same kind of run. If you want a reference point, the VO2max by age chart shows where you sit now. The rest of the engine articles are on the engine hub.

Questions

What is the best interval workout for VO2max?
The best-known trial is Helgerud 2007: 4 x 4 minutes at 90 to 95% of max heart rate with 3 minutes of easy jogging between, three times a week for 8 weeks, raised VO2max by 7.2% in moderately trained men, more than the same total work done at an easy or threshold pace. Meta-analyses show both intervals and steady training raise VO2max, with intervals slightly ahead.
Will interval training make me lose muscle?
A 2018 meta-analysis found that adding high-intensity intervals to resistance training didn't change muscle growth or upper-body strength gains, but lower-body strength gains were slightly smaller (effect size -0.25). Keeping intervals away from heavy leg sessions is the simplest way to limit that.
Should I do intervals on a bike or running if I lift?
The evidence conflicts. One meta-analysis found running, not cycling, hurt strength and hypertrophy outcomes; another found a trend the other way for intervals; the largest recent one found no difference between the two. Pick the one your legs tolerate best around your lifting days.

Where do your two halves stand? Get your score, free.

Sources

  1. 01Helgerud J, Høydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J. Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc. 2007;39(4):665-671. doi.org/10.1249/mss.0b013e3180304570↩Checked 22 October 2026
  2. 02Milanović Z, Sporiš G, Weston M. Effectiveness of high-intensity interval training (HIT) and continuous endurance training for VO2max improvements: a systematic review and meta-analysis of controlled trials. Sports Med. 2015;45(10):1469-1481. doi.org/10.1007/s40279-015-0365-0↩Checked 22 October 2026
  3. 03Bacon AP, Carter RE, Ogle EA, Joyner MJ. VO2max trainability and high intensity interval training in humans: a meta-analysis. PLoS One. 2013;8(9):e73182. doi.org/10.1371/journal.pone.0073182↩Checked 22 October 2026
  4. 04Bassett DR, Howley ET. Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc. 2000;32(1):70-84. doi.org/10.1097/00005768-200001000-00012↩Checked 22 October 2026
  5. 05Nes BM, Janszky I, Wisløff U, Støylen A, Karlsen T. Age-predicted maximal heart rate in healthy subjects: the HUNT Fitness Study. Scand J Med Sci Sports. 2013;23(6):697-704. doi.org/10.1111/j.1600-0838.2012.01445.x↩Checked 22 October 2026
  6. 06Sabag A, Najafi A, Michael S, Esgin T, Halaki M, Hackett D. The compatibility of concurrent high intensity interval training and resistance training for muscular strength and hypertrophy: a systematic review and meta-analysis. J Sports Sci. 2018;36(21):2472-2483. doi.org/10.1080/02640414.2018.1464636↩Checked 22 October 2026
  7. 07Schumann M, Feuerbacher JF, Sünkeler M, Freitag N, Rønnestad BR, Doma K, Lundberg TR. Compatibility of concurrent aerobic and strength training for skeletal muscle size and function: an updated systematic review and meta-analysis. Sports Med. 2022;52(3):601-612. doi.org/10.1007/s40279-021-01587-7↩Checked 22 October 2026
  8. 08Petré H, Hemmingsson E, Rosdahl H, Psilander N. Development of maximal dynamic strength during concurrent resistance and endurance training in untrained, moderately trained, and trained individuals: a systematic review and meta-analysis. Sports Med. 2021;51(5):991-1010. doi.org/10.1007/s40279-021-01426-9↩Checked 22 October 2026
  9. 09Wilson JM, Marin PJ, Rhea MR, Wilson SM, Loenneke JP, Anderson JC. Concurrent training: a meta-analysis examining interference of aerobic and resistance exercises. J Strength Cond Res. 2012;26(8):2293-2307. doi.org/10.1519/JSC.0b013e31823a3e2d↩Checked 22 October 2026
  10. 10Silva Oliveira P, Boppre G, Fonseca H. Comparison of polarized versus other types of endurance training intensity distribution on athletes' endurance performance: a systematic review with meta-analysis. Sports Med. 2024;54(8):2071-2095. doi.org/10.1007/s40279-024-02034-z↩Checked 22 October 2026